Salem would leave the G-MAC in 2016 to become a Division II independent. On October 16, 2012, the G-MAC announced that Salem International University, since renamed Salem University, would join the conference on July 1, 2013. All three schools were previously members of the West Virginia Intercollegiate Athletic Conference (WVIAC), which disbanded after most of its football-sponsoring schools announced their departure for a new D-II league that eventually became the Mountain East Conference (MEC). At the same time, the G-MAC announced that three West Virginia schools had accepted invitations to join the conference, starting in July 2013- Alderson Broaddus University, Davis & Elkins College, and Ohio Valley University. In the fall of 2012, it was announced that Urbana and UVA Wise would spend only one season as active members of the G-MAC. As of 2021, Georgetown has made no further attempt to join Division II. However, they were denied acceptance once again by the Membership Council. Georgetown College was rejected for Division II membership, but applied to join Division II in 2014. The conference then added two more members when it was announced on April 23 and May 1, 2012, that the University of Virginia's College at Wise (UVA Wise) and Georgetown College had been granted provisional membership in the conference pending their approval by the NCAA Division II Membership Committee. On Februthe Great Midwest Athletic Conference announced the NCAA had accepted the G-MAC as the 24th NCAA Division ll conference. In late November, the conference announced the hiring of Tom Daeger as Conference Commissioner, with offices in Indianapolis.
Trevecca had begun the process of transitioning from NAIA to NCAA Division II membership in July, 2011 and entered a provisional NCAA membership year during the conference's initially planned start for the 2013–14 academic year. In November 2011, Trevecca Nazarene University was accepted as another charter member of the conference. In October 2011, Kentucky Wesleyan College announced that the school will join the G-MAC, withdrawing from its current conference, the Great Lakes Valley Conference. Soon after the initial meeting, Central State University joined and became a fifth member. The initial announcement of a potential new conference surfaced in June 2011 when the presidents and athletic directors of Cedarville University, Notre Dame College, Urbana University, and Ursuline College met to discuss plans for a new Division II conference. Location of G-MAC members: full, affiliate, and future